2ahe: Difference between revisions
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<StructureSection load='2ahe' size='340' side='right'caption='[[2ahe]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='2ahe' size='340' side='right'caption='[[2ahe]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ahe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2ahe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AHE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AHE FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ahe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ahe OCA], [https://pdbe.org/2ahe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ahe RCSB], [https://www.ebi.ac.uk/pdbsum/2ahe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ahe ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ahe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ahe OCA], [https://pdbe.org/2ahe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ahe RCSB], [https://www.ebi.ac.uk/pdbsum/2ahe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ahe ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/CLIC4_HUMAN CLIC4_HUMAN] Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).<ref>PMID:12163372</ref> <ref>PMID:14569596</ref> <ref>PMID:16239224</ref> <ref>PMID:18302930</ref> <ref>PMID:19247789</ref> <ref>PMID:16176272</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Aguilar | [[Category: Aguilar M-I]] | ||
[[Category: Assaad | [[Category: Assaad NN]] | ||
[[Category: Berryman | [[Category: Berryman MA]] | ||
[[Category: Breit | [[Category: Breit SN]] | ||
[[Category: Brown | [[Category: Brown LJ]] | ||
[[Category: Curmi | [[Category: Curmi PMG]] | ||
[[Category: Harrop | [[Category: Harrop SJ]] | ||
[[Category: Littler | [[Category: Littler DR]] | ||
[[Category: Luciani | [[Category: Luciani P]] | ||
[[Category: Mazzanti | [[Category: Mazzanti M]] | ||
[[Category: Pankhurst | [[Category: Pankhurst GJ]] | ||
