2dsr: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
Line 3: Line 3:
<StructureSection load='2dsr' size='340' side='right'caption='[[2dsr]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='2dsr' size='340' side='right'caption='[[2dsr]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2dsr]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DSR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DSR FirstGlance]. <br>
<table><tr><td colspan='2'>[[2dsr]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DSR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DSR FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1wqj|1wqj]], [[2dsp|2dsp]], [[2dsq|2dsq]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dsr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dsr OCA], [https://pdbe.org/2dsr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dsr RCSB], [https://www.ebi.ac.uk/pdbsum/2dsr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dsr ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dsr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dsr OCA], [https://pdbe.org/2dsr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dsr RCSB], [https://www.ebi.ac.uk/pdbsum/2dsr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dsr ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[[https://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN]] Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:[https://omim.org/entry/608747 608747]]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/IBP4_HUMAN IBP4_HUMAN]] IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. [[https://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN]] The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.<ref>PMID:21076856</ref> 
[https://www.uniprot.org/uniprot/IBP4_HUMAN IBP4_HUMAN] IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 38: Line 36:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Holak, T A]]
[[Category: Holak TA]]
[[Category: Huber, R]]
[[Category: Huber R]]
[[Category: Popowicz, G M]]
[[Category: Popowicz GM]]
[[Category: Sitar, T]]
[[Category: Sitar T]]
[[Category: Siwanowicz, I]]
[[Category: Siwanowicz I]]
[[Category: Igf]]
[[Category: Igfbp]]
[[Category: Insulin]]
[[Category: Protein binding-hormone-growth factor complex]]
Retrieved from "https://proteopedia.org/2dsr"