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<StructureSection load='2dvn' size='340' side='right'caption='[[2dvn]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='2dvn' size='340' side='right'caption='[[2dvn]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2dvn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/'pyrococcus_shinkaii' 'pyrococcus shinkaii']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DVN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DVN FirstGlance]. <br>
<table><tr><td colspan='2'>[[2dvn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DVN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DVN FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2dvo|2dvo]], [[2dvp|2dvp]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dvn OCA], [https://pdbe.org/2dvn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dvn RCSB], [https://www.ebi.ac.uk/pdbsum/2dvn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dvn ProSAT], [https://www.topsan.org/Proteins/RSGI/2dvn TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dvn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dvn OCA], [https://pdbe.org/2dvn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dvn RCSB], [https://www.ebi.ac.uk/pdbsum/2dvn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dvn ProSAT], [https://www.topsan.org/Proteins/RSGI/2dvn TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/NTPA_PYRHO NTPA_PYRHO]] Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (Probable).<ref>PMID:18062990</ref>
[https://www.uniprot.org/uniprot/IXTPA_PYRHO IXTPA_PYRHO] Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.[HAMAP-Rule:MF_01405]<ref>PMID:18062990</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Pyrococcus shinkaii]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lokanath, N K]]
[[Category: Pyrococcus horikoshii]]
[[Category: Structural genomic]]
[[Category: Lokanath NK]]
[[Category: Hydrolase]]
[[Category: Imp]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Ntpase]]
[[Category: Rsgi]]
Retrieved from "https://proteopedia.org/2dvn"