2h4r: Difference between revisions

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<StructureSection load='2h4r' size='340' side='right'caption='[[2h4r]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='2h4r' size='340' side='right'caption='[[2h4r]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2h4r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H4R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H4R FirstGlance]. <br>
<table><tr><td colspan='2'>[[2h4r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H4R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H4R FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2h4p|2h4p]], [[2h4q|2h4q]], [[2h4s|2h4s]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ment-1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h4r OCA], [https://pdbe.org/2h4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h4r RCSB], [https://www.ebi.ac.uk/pdbsum/2h4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h4r ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h4r OCA], [https://pdbe.org/2h4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h4r RCSB], [https://www.ebi.ac.uk/pdbsum/2h4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h4r ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/SPB10_CHICK SPB10_CHICK]] DNA-binding protein that promotes DNA condensation into transcriptionally inactive heterochromatin in terminally differentiated avian blood cells. Promotes tight packing of nucleosomes into spherical clusters by binding to linker DNA and subsequent oligomerization. Acts as a cysteine protease inhibitor towards CTSL (cathepsin L1) and CTSV (cathepsin L2), but does not inhibit serine proteases.<ref>PMID:10026180</ref> <ref>PMID:11821386</ref> <ref>PMID:12930828</ref> <ref>PMID:16810322</ref> <ref>PMID:9446625</ref>
[https://www.uniprot.org/uniprot/SPB10_CHICK SPB10_CHICK] DNA-binding protein that promotes DNA condensation into transcriptionally inactive heterochromatin in terminally differentiated avian blood cells. Promotes tight packing of nucleosomes into spherical clusters by binding to linker DNA and subsequent oligomerization. Acts as a cysteine protease inhibitor towards CTSL (cathepsin L1) and CTSV (cathepsin L2), but does not inhibit serine proteases.<ref>PMID:10026180</ref> <ref>PMID:11821386</ref> <ref>PMID:12930828</ref> <ref>PMID:16810322</ref> <ref>PMID:9446625</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Chick]]
[[Category: Gallus gallus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Buckle, A M]]
[[Category: Buckle AM]]
[[Category: Irving, J A]]
[[Category: Irving JA]]
[[Category: McGowan, S]]
[[Category: McGowan S]]
[[Category: Whisstock, J C]]
[[Category: Whisstock JC]]
[[Category: Hydrolase inhibitor]]
[[Category: Serine protease inhibitor]]
[[Category: Serpin]]
Retrieved from "https://proteopedia.org/2h4r"