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'''THE CRYSTAL STRUCTURE OF NEUROTOXIN-I FROM NAJA NAJA OXIANA AT 1.9 ANGSTROMS RESOLUTION''' | '''THE CRYSTAL STRUCTURE OF NEUROTOXIN-I FROM NAJA NAJA OXIANA AT 1.9 ANGSTROMS RESOLUTION''' | ||
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[[Category: Vainshtein, B K.]] | [[Category: Vainshtein, B K.]] | ||
[[Category: Wilson, K.]] | [[Category: Wilson, K.]] | ||
[[Category: | [[Category: Postsynaptic neurotoxin]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:57:53 2008'' | |||
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Revision as of 23:57, 2 May 2008
THE CRYSTAL STRUCTURE OF NEUROTOXIN-I FROM NAJA NAJA OXIANA AT 1.9 ANGSTROMS RESOLUTION
Overview
Neurotoxin-1 from Naja naja oxiana venom (NTX-1) has been crystallized by vapor diffusion in sitting drops. The crystals have cell dimensions of a = 25.2 A, b = 75.6 A, c = 35.9 A, and are in space group P2(1)2(1)2(1). Three-dimensional data to 1.9 A have been recorded by a Syntex P2(1) automatic diffractometer. The atomic structure of the toxin has been determined by molecular replacement using the alpha-cobratoxin (alpha-CTX) as the search model. The position of 534 non-hydrogen protein atoms have been determined. The model contains 65 water molecules. Refinement has led to an R-factor of 19.3% at 1.9 A resolution. The secondary and tertiary structures of NTX-1 have been analyzed and a comparison with structure of the alpha-CTX has been made.
About this Structure
1NTN is a Single protein structure of sequence from Naja oxiana. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of neurotoxin-1 from Naja naja oxiana venom at 1.9 A resolution., Nickitenko AV, Michailov AM, Betzel C, Wilson KS, FEBS Lett. 1993 Apr 5;320(2):111-7. PMID:8458425 Page seeded by OCA on Sat May 3 02:57:53 2008
