8t6b: Difference between revisions
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The entry | ==Human VMAT2 in complex with serotonin== | ||
<StructureSection load='8t6b' size='340' side='right'caption='[[8t6b]], [[Resolution|resolution]] 3.72Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8t6b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8T6B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8T6B FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.72Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SRO:SEROTONIN'>SRO</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8t6b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8t6b OCA], [https://pdbe.org/8t6b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8t6b RCSB], [https://www.ebi.ac.uk/pdbsum/8t6b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8t6b ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/VMAT2_HUMAN VMAT2_HUMAN] Brain dopamine-serotonin vesicular transport disease. The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/VMAT2_HUMAN VMAT2_HUMAN] Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports a variety of catecholamines such as dopamine, adrenaline and noradrenaline, histamine, and indolamines such as serotonin (PubMed:8643547, PubMed:23363473). Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates somatodendritic dopamine release in hippocampal neurons, likely as part of a regulated secretory pathway that integrates retrograde synaptic signals (By similarity). Acts as a primary transporter for striatal dopamine loading ensuring impulse-dependent release of dopamine at the synaptic cleft (By similarity). Responsible for histamine and serotonin storage and subsequent corelease from mast cell granules (PubMed:8860238) (By similarity).[UniProtKB:Q01827][UniProtKB:Q8BRU6]<ref>PMID:23363473</ref> <ref>PMID:8643547</ref> <ref>PMID:8860238</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Dai Y]] | |||
[[Category: Lee CH]] | |||
[[Category: Pidathala S]] | |||
Latest revision as of 13:15, 1 November 2023
Human VMAT2 in complex with serotonin
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