2zam: Difference between revisions
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<StructureSection load='2zam' size='340' side='right'caption='[[2zam]], [[Resolution|resolution]] 3.50Å' scene=''> | <StructureSection load='2zam' size='340' side='right'caption='[[2zam]], [[Resolution|resolution]] 3.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2zam]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2zam]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZAM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZAM FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zam OCA], [https://pdbe.org/2zam PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zam RCSB], [https://www.ebi.ac.uk/pdbsum/2zam PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zam ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zam OCA], [https://pdbe.org/2zam PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zam RCSB], [https://www.ebi.ac.uk/pdbsum/2zam PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zam ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/VPS4B_MOUSE VPS4B_MOUSE] Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (By similarity).<ref>PMID:10393249</ref> <ref>PMID:10679028</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Inoue | [[Category: Inoue M]] | ||
[[Category: Kamikubo | [[Category: Kamikubo H]] | ||
[[Category: Kataoka | [[Category: Kataoka M]] | ||
[[Category: Kato | [[Category: Kato R]] | ||
[[Category: Kawasaki | [[Category: Kawasaki M]] | ||
[[Category: Wakatsuki | [[Category: Wakatsuki S]] | ||
[[Category: Yoshimori | [[Category: Yoshimori T]] | ||
