2zfa: Difference between revisions

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<StructureSection load='2zfa' size='340' side='right'caption='[[2zfa]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
<StructureSection load='2zfa' size='340' side='right'caption='[[2zfa]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2zfa]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"gaffkya_homari"_hitchner_and_snieszko_1947 "gaffkya homari" hitchner and snieszko 1947]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZFA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2ZFA FirstGlance]. <br>
<table><tr><td colspan='2'>[[2zfa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aerococcus_viridans Aerococcus viridans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZFA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZFA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.81&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2nli|2nli]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lactate_2-monooxygenase Lactate 2-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.12.4 1.13.12.4] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zfa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zfa OCA], [https://pdbe.org/2zfa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zfa RCSB], [https://www.ebi.ac.uk/pdbsum/2zfa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zfa ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2zfa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zfa OCA], [http://pdbe.org/2zfa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zfa RCSB], [http://www.ebi.ac.uk/pdbsum/2zfa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zfa ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LOX_AERVM LOX_AERVM] Catalyzes the oxidation of (S)-lactate (L-lactate) to pyruvate, with a reduction of O2 to H2O2 (Ref.1, PubMed:27302031, PubMed:25423902, PubMed:2818595, PubMed:8589073, PubMed:26260739). Cannot oxidize D-lactate, glycolate, and D,L-2-hydroxybutanoate (PubMed:2818595). May be involved in the utilization of L-lactate as an energy source for growth (By similarity).[UniProtKB:O33655]<ref>PMID:25423902</ref> <ref>PMID:26260739</ref> <ref>PMID:27302031</ref> <ref>PMID:2818595</ref> <ref>PMID:8589073</ref> [UniProtKB:O33655]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 2zfa" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2zfa" style="background-color:#fffaf0;"></div>
==See Also==
*[[Monooxygenase 3D structures|Monooxygenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Gaffkya homari hitchner and snieszko 1947]]
[[Category: Aerococcus viridans]]
[[Category: Lactate 2-monooxygenase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Balasundaresan, D]]
[[Category: Balasundaresan D]]
[[Category: Furuichi, M]]
[[Category: Furuichi M]]
[[Category: Kaneko, H]]
[[Category: Kaneko H]]
[[Category: Kumar, P K.R]]
[[Category: Kumar PKR]]
[[Category: Minagawa, H]]
[[Category: Minagawa H]]
[[Category: Mizuno, H]]
[[Category: Mizuno H]]
[[Category: Suzuki, N]]
[[Category: Suzuki N]]
[[Category: Waga, I]]
[[Category: Waga I]]
[[Category: Yoshida, Y]]
[[Category: Yoshida Y]]
[[Category: D-lactate]]
[[Category: Flavoenzyme]]
[[Category: Flavoprotein]]
[[Category: Fmn]]
[[Category: L-lactate oxidase]]
[[Category: Oxidoreductase]]