2zyf: Difference between revisions
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<StructureSection load='2zyf' size='340' side='right'caption='[[2zyf]], [[Resolution|resolution]] 2.15Å' scene=''> | <StructureSection load='2zyf' size='340' side='right'caption='[[2zyf]], [[Resolution|resolution]] 2.15Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2zyf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2zyf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB27 Thermus thermophilus HB27]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZYF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZYF FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zyf OCA], [https://pdbe.org/2zyf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zyf RCSB], [https://www.ebi.ac.uk/pdbsum/2zyf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zyf ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zyf OCA], [https://pdbe.org/2zyf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zyf RCSB], [https://www.ebi.ac.uk/pdbsum/2zyf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zyf ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/HOSA_THET2 HOSA_THET2] Catalyzes the aldol-type condensation of 2-oxoglutarate with acetyl-CoA to yield homocitrate (PubMed:19996101, PubMed:12095615). Carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway (PubMed:9868782). To a lesser extent, can also use oxaloacetate in place of 2-oxoglutarate, leading to citrate. Does not display 2-isopropylmalate synthase activity since it cannot use 2-oxoisovalerate (PubMed:12095615).<ref>PMID:12095615</ref> <ref>PMID:19996101</ref> <ref>PMID:9868782</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Thermus thermophilus HB27]] | ||
[[Category: Kuzuyama | [[Category: Kuzuyama T]] | ||
[[Category: Nishiyama | [[Category: Nishiyama M]] | ||
[[Category: Okada | [[Category: Okada T]] | ||
[[Category: Tomita | [[Category: Tomita T]] | ||
