3b6h: Difference between revisions

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<StructureSection load='3b6h' size='340' side='right'caption='[[3b6h]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
<StructureSection load='3b6h' size='340' side='right'caption='[[3b6h]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3b6h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B6H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B6H FirstGlance]. <br>
<table><tr><td colspan='2'>[[3b6h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B6H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B6H FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MXD:6-PIPERIDIN-1-YLPYRIMIDINE-2,4-DIAMINE+3-OXIDE'>MXD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.62&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2iag|2iag]], [[3b98|3b98]], [[3b99|3b99]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MXD:6-PIPERIDIN-1-YLPYRIMIDINE-2,4-DIAMINE+3-OXIDE'>MXD</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTGIS, CYP8, CYP8A1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Prostaglandin-I_synthase Prostaglandin-I synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.4 5.3.99.4] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b6h OCA], [https://pdbe.org/3b6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b6h RCSB], [https://www.ebi.ac.uk/pdbsum/3b6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b6h ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b6h OCA], [https://pdbe.org/3b6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b6h RCSB], [https://www.ebi.ac.uk/pdbsum/3b6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b6h ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/PTGIS_HUMAN PTGIS_HUMAN]] Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).  
[https://www.uniprot.org/uniprot/PTGIS_HUMAN PTGIS_HUMAN] Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Prostaglandin-I synthase]]
[[Category: Chan N-L]]
[[Category: Chan, N L]]
[[Category: Chiang C-W]]
[[Category: Chiang, C W]]
[[Category: Hsu P-Y]]
[[Category: Hsu, P Y]]
[[Category: Li Y-C]]
[[Category: Li, Y C]]
[[Category: Wang L-H]]
[[Category: Wang, L H]]
[[Category: Whitby FG]]
[[Category: Whitby, F G]]
[[Category: Yeh H-C]]
[[Category: Yeh, H C]]
[[Category: Cyp8a1]]
[[Category: Cytochrome p450]]
[[Category: Endoplasmic reticulum]]
[[Category: Enzyme-inhibitor complex]]
[[Category: Fatty acid biosynthesis]]
[[Category: Heme]]
[[Category: Iron]]
[[Category: Isomerase]]
[[Category: Lipid synthesis]]
[[Category: Membrane]]
[[Category: Metal-binding]]
[[Category: Polymorphism]]
[[Category: Prostacyclin synthase]]
[[Category: Prostaglandin biosynthesis]]
[[Category: Transmembrane]]
Retrieved from "https://proteopedia.org/3b6h"