3dtm: Difference between revisions

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<StructureSection load='3dtm' size='340' side='right'caption='[[3dtm]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='3dtm' size='340' side='right'caption='[[3dtm]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3dtm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecobd Ecobd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DTM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DTM FirstGlance]. <br>
<table><tr><td colspan='2'>[[3dtm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_BL21(DE3) Escherichia coli BL21(DE3)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DTM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DTM FirstGlance]. <br>
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dtm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dtm OCA], [https://pdbe.org/3dtm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dtm RCSB], [https://www.ebi.ac.uk/pdbsum/3dtm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dtm ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dtm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dtm OCA], [https://pdbe.org/3dtm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dtm RCSB], [https://www.ebi.ac.uk/pdbsum/3dtm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dtm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BLAT_ECOLX BLAT_ECOLX] TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Beta-lactamase]]
[[Category: Ecobd]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Dobbek, H]]
[[Category: Dobbek H]]
[[Category: Jakob, R P]]
[[Category: Jakob RP]]
[[Category: Kather, I]]
[[Category: Kather I]]
[[Category: Schmid, F X]]
[[Category: Schmid FX]]
[[Category: Antibiotic resistance]]
[[Category: Hydrolase]]
[[Category: Plasmid]]
[[Category: Tem-1 beta-lactamase]]
Retrieved from "https://proteopedia.org/3dtm"