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<StructureSection load='3gus' size='340' side='right'caption='[[3gus]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
<StructureSection load='3gus' size='340' side='right'caption='[[3gus]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3gus]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GUS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3GUS FirstGlance]. <br>
<table><tr><td colspan='2'>[[3gus]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GUS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GUS FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=N11:6-[(7-NITRO-2,1,3-BENZOXADIAZOL-4-YL)SULFANYL]HEXAN-1-OL'>N11</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.53&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3gur|3gur]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=N11:6-[(7-NITRO-2,1,3-BENZOXADIAZOL-4-YL)SULFANYL]HEXAN-1-OL'>N11</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gus OCA], [https://pdbe.org/3gus PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gus RCSB], [https://www.ebi.ac.uk/pdbsum/3gus PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gus ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3gus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gus OCA], [http://pdbe.org/3gus PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3gus RCSB], [http://www.ebi.ac.uk/pdbsum/3gus PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3gus ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GSTP1_HUMAN GSTP1_HUMAN]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.<ref>PMID:21668448</ref>
[https://www.uniprot.org/uniprot/GSTP1_HUMAN GSTP1_HUMAN] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.<ref>PMID:21668448</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 3gus" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3gus" style="background-color:#fffaf0;"></div>
==See Also==
*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Glutathione transferase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Caccuri, A M]]
[[Category: Caccuri AM]]
[[Category: Federici, G]]
[[Category: Di Matteo A]]
[[Category: Federici, L]]
[[Category: Federici G]]
[[Category: Matteo, A Di]]
[[Category: Federici L]]
[[Category: Scaloni, F]]
[[Category: Lo Sterzo C]]
[[Category: Sterzo, C Lo]]
[[Category: Scaloni F]]
[[Category: Gstp1-1 in complex with glutathione and nbdhex]]
[[Category: Phosphoprotein]]
[[Category: Transferase-transferase inhibitor complex]]
Retrieved from "https://proteopedia.org/3gus"