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==Crystal structure of the BC domain of ACC2 in complex with soraphen A==
==Crystal structure of the BC domain of ACC2 in complex with soraphen A==
<StructureSection load='3jrx' size='340' side='right' caption='[[3jrx]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='3jrx' size='340' side='right'caption='[[3jrx]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3jrx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JRX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JRX FirstGlance]. <br>
<table><tr><td colspan='2'>[[3jrx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JRX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JRX FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=S1A:SORAPHEN+A'>S1A</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2hjw|2hjw]], [[3jrw|3jrw]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=S1A:SORAPHEN+A'>S1A</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ACACB, ACC2, ACCB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jrx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jrx OCA], [https://pdbe.org/3jrx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jrx RCSB], [https://www.ebi.ac.uk/pdbsum/3jrx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jrx ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jrx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jrx OCA], [http://pdbe.org/3jrx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jrx RCSB], [http://www.ebi.ac.uk/pdbsum/3jrx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3jrx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ACACB_HUMAN ACACB_HUMAN]] ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.  
[https://www.uniprot.org/uniprot/ACACB_HUMAN ACACB_HUMAN] ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Acetyl-CoA carboxylase|Acetyl-CoA carboxylase]]
*[[Acetyl-CoA carboxylase 3D structures|Acetyl-CoA carboxylase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Cho, Y S]]
[[Category: Large Structures]]
[[Category: Heo, Y S]]
[[Category: Cho YS]]
[[Category: Kim, H T]]
[[Category: Heo YS]]
[[Category: Lee, J I]]
[[Category: Kim HT]]
[[Category: Lee, T G]]
[[Category: Lee JI]]
[[Category: Shin, D]]
[[Category: Lee TG]]
[[Category: Alternative splicing]]
[[Category: Shin D]]
[[Category: Atp-binding]]
[[Category: Bc domain]]
[[Category: Biotin]]
[[Category: Fatty acid biosynthesis]]
[[Category: Ligase]]
[[Category: Lipid synthesis]]
[[Category: Manganese]]
[[Category: Membrane]]
[[Category: Metal-binding]]
[[Category: Multifunctional enzyme]]
[[Category: Nucleotide-binding]]
[[Category: Phosphoprotein]]
[[Category: Polymorphism]]
[[Category: Soraphen some]]
Retrieved from "https://proteopedia.org/3jrx"