3l2c: Difference between revisions

<StructureSection load='3l2c' size='340' side='right'caption='[[3l2c]], [[Resolution|resolution]] 1.87&Aring;' scene=''>

<table><tr><td colspan='2'>[[3l2c]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3bpy 3bpy]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L2C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L2C FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.868&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l2c OCA], [https://pdbe.org/3l2c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l2c RCSB], [https://www.ebi.ac.uk/pdbsum/3l2c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l2c ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/FOXO4_HUMAN FOXO4_HUMAN] A chromosomal aberration involving FOXO4 is found in acute leukemias. Translocation t(X;11)(q13;q23) with KMT2A/MLL1. The result is a rogue activator protein.

[https://www.uniprot.org/uniprot/FOXO4_HUMAN FOXO4_HUMAN] Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity.<ref>PMID:10217147</ref> <ref>PMID:10783894</ref> <ref>PMID:12761217</ref> <ref>PMID:15126506</ref> <ref>PMID:16054032</ref> <ref>PMID:16964248</ref> <ref>PMID:20874444</ref> <ref>PMID:22972301</ref>  

*[[FOX 3D structures|FOX 3D structures]]

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Boura E]]

[[Category: Brynda J]]

[[Category: Obsil T]]

[[Category: Obsilova V]]

[[Category: Silhan J]]

[[Category: Sulc M]]