3l9b: Difference between revisions

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<StructureSection load='3l9b' size='340' side='right'caption='[[3l9b]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='3l9b' size='340' side='right'caption='[[3l9b]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3l9b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L9B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L9B FirstGlance]. <br>
<table><tr><td colspan='2'>[[3l9b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L9B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L9B FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Fer1l2, Otof ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l9b OCA], [https://pdbe.org/3l9b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l9b RCSB], [https://www.ebi.ac.uk/pdbsum/3l9b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l9b ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l9b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l9b OCA], [https://pdbe.org/3l9b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l9b RCSB], [https://www.ebi.ac.uk/pdbsum/3l9b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l9b ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/OTOF_RAT OTOF_RAT]] Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses. Interacts in a calcium-dependent manner to the presynaptic SNARE proteins at ribbon synapses of cochlear inner hair cells (IHCs) to trigger exocytosis of neurotransmitter. Also essential to synaptic exocytosis in immature outer hair cells (OHCs). May also play a role within the recycling of endosomes (By similarity).  
[https://www.uniprot.org/uniprot/OTOF_RAT OTOF_RAT] Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses. Interacts in a calcium-dependent manner to the presynaptic SNARE proteins at ribbon synapses of cochlear inner hair cells (IHCs) to trigger exocytosis of neurotransmitter. Also essential to synaptic exocytosis in immature outer hair cells (OHCs). May also play a role within the recycling of endosomes (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Helfmann, S]]
[[Category: Rattus norvegicus]]
[[Category: Neumann, P]]
[[Category: Helfmann S]]
[[Category: Beta-sheet]]
[[Category: Neumann P]]
[[Category: C2-domain]]
[[Category: Cell membrane]]
[[Category: Hearing]]
[[Category: Membrane]]
[[Category: Membrane protein]]
[[Category: Otoferlin]]
[[Category: Synapse]]
[[Category: Synaptic vesicle]]
[[Category: Transmembrane]]
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