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==Crystal structure of Brd4 bromodomain 1 with propionylated histone H3-K(prop)23==
==Crystal structure of Brd4 bromodomain 1 with propionylated histone H3-K(prop)23==
<StructureSection load='3muk' size='340' side='right' caption='[[3muk]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
<StructureSection load='3muk' size='340' side='right'caption='[[3muk]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3muk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MUK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MUK FirstGlance]. <br>
<table><tr><td colspan='2'>[[3muk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MUK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MUK FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PRK:N~6~-PROPANOYL-L-LYSINE'>PRK</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PRK:N~6~-PROPANOYL-L-LYSINE'>PRK</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3jvk|3jvk]], [[3jvj|3jvj]], [[3mul|3mul]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3muk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3muk OCA], [https://pdbe.org/3muk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3muk RCSB], [https://www.ebi.ac.uk/pdbsum/3muk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3muk ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Brd4, Mcap ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3muk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3muk OCA], [http://pdbe.org/3muk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3muk RCSB], [http://www.ebi.ac.uk/pdbsum/3muk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3muk ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/BRD4_MOUSE BRD4_MOUSE]] Plays a role in a process governing chromosomal dynamics during mitosis.<ref>PMID:10938129</ref>
[https://www.uniprot.org/uniprot/BRD4_MOUSE BRD4_MOUSE] Plays a role in a process governing chromosomal dynamics during mitosis.<ref>PMID:10938129</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Bromodomain-containing protein|Bromodomain-containing protein]]
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Homo sapiens]]
[[Category: Geyer, M]]
[[Category: Large Structures]]
[[Category: Vollmuth, F]]
[[Category: Mus musculus]]
[[Category: Acylation]]
[[Category: Geyer M]]
[[Category: Bromodomain]]
[[Category: Vollmuth F]]
[[Category: Histone recognition]]
[[Category: N-propionyl lysine]]
[[Category: Signaling protein]]
Retrieved from "https://proteopedia.org/3muk"