3n9o: Difference between revisions

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==ceKDM7A from C.elegans, complex with H3K4me3 peptide, H3K9me2 peptide and NOG==
==ceKDM7A from C.elegans, complex with H3K4me3 peptide, H3K9me2 peptide and NOG==
<StructureSection load='3n9o' size='340' side='right' caption='[[3n9o]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
<StructureSection load='3n9o' size='340' side='right'caption='[[3n9o]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3n9o]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N9O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N9O FirstGlance]. <br>
<table><tr><td colspan='2'>[[3n9o]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N9O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N9O FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=OGA:N-OXALYLGLYCINE'>OGA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.309&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene>, <scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene>, <scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=OGA:N-OXALYLGLYCINE'>OGA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3n9l|3n9l]], [[3n9m|3n9m]], [[3n9n|3n9n]], [[3n9p|3n9p]], [[3n9q|3n9q]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n9o OCA], [https://pdbe.org/3n9o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n9o RCSB], [https://www.ebi.ac.uk/pdbsum/3n9o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n9o ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">F29B9.2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/[Histone_H3]-lysine-36_demethylase [Histone H3]-lysine-36 demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.11.27 1.14.11.27] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n9o OCA], [http://pdbe.org/3n9o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3n9o RCSB], [http://www.ebi.ac.uk/pdbsum/3n9o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3n9o ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/KDM7_CAEEL KDM7_CAEEL]] Histone demethylase required for nervous system development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code.<ref>PMID:20567262</ref> <ref>PMID:20346720</ref> <ref>PMID:20567261</ref>
[https://www.uniprot.org/uniprot/KDM7_CAEEL KDM7_CAEEL] Histone demethylase required for nervous system development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code.<ref>PMID:20567262</ref> <ref>PMID:20346720</ref> <ref>PMID:20567261</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Caeel]]
[[Category: Caenorhabditis elegans]]
[[Category: Chen, C D]]
[[Category: Large Structures]]
[[Category: Hou, H]]
[[Category: Chen CD]]
[[Category: Hu, L]]
[[Category: Hou H]]
[[Category: Wang, P]]
[[Category: Hu L]]
[[Category: Xu, Y]]
[[Category: Wang P]]
[[Category: Yang, Y]]
[[Category: Xu Y]]
[[Category: Demethylase]]
[[Category: Yang Y]]
[[Category: Histone]]
[[Category: Jmjc]]
[[Category: Methylation]]
[[Category: Oxidoreductase]]
[[Category: Phd]]
Retrieved from "https://proteopedia.org/3n9o"