3nw2: Difference between revisions

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<StructureSection load='3nw2' size='340' side='right'caption='[[3nw2]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='3nw2' size='340' side='right'caption='[[3nw2]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3nw2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NW2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3nw2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NW2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MPW:2-[2-(4-METHOXYPYRIDIN-2-YL)ETHYL]-3H-IMIDAZO[4,5-B]PYRIDINE'>MPW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1nod|1nod]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MPW:2-[2-(4-METHOXYPYRIDIN-2-YL)ETHYL]-3H-IMIDAZO[4,5-B]PYRIDINE'>MPW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nw2 OCA], [https://pdbe.org/3nw2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nw2 RCSB], [https://www.ebi.ac.uk/pdbsum/3nw2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nw2 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nw2 OCA], [https://pdbe.org/3nw2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nw2 RCSB], [https://www.ebi.ac.uk/pdbsum/3nw2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nw2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE]] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>
[https://www.uniprot.org/uniprot/NOS2_MOUSE NOS2_MOUSE] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.<ref>PMID:16373578</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Anezo, C]]
[[Category: Anezo C]]
[[Category: Boer, R]]
[[Category: Boer R]]
[[Category: Diederichs, K]]
[[Category: Diederichs K]]
[[Category: Fuchss, T]]
[[Category: Fuchss T]]
[[Category: Graedler, U]]
[[Category: Graedler U]]
[[Category: Hesslinger, C]]
[[Category: Hesslinger C]]
[[Category: Strub, A]]
[[Category: Strub A]]
[[Category: Ulrich, W R]]
[[Category: Ulrich WR]]
[[Category: Zaliani, A]]
[[Category: Zaliani A]]
[[Category: Calmodulin-binding]]
[[Category: Fad]]
[[Category: Fmn]]
[[Category: Iron]]
[[Category: Metal-binding]]
[[Category: Nadp]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
Retrieved from "https://proteopedia.org/3nw2"