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<StructureSection load='3orf' size='340' side='right'caption='[[3orf]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
<StructureSection load='3orf' size='340' side='right'caption='[[3orf]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3orf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Dicdi Dicdi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ORF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ORF FirstGlance]. <br>
<table><tr><td colspan='2'>[[3orf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ORF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ORF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.16&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ooe|1ooe]], [[1hdr|1hdr]], [[1dir|1dir]], [[1dhr|1dhr]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DDB_G0272684, qdpr ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=44689 DICDI])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/6,7-dihydropteridine_reductase 6,7-dihydropteridine reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.34 1.5.1.34] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3orf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3orf OCA], [https://pdbe.org/3orf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3orf RCSB], [https://www.ebi.ac.uk/pdbsum/3orf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3orf ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3orf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3orf OCA], [https://pdbe.org/3orf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3orf RCSB], [https://www.ebi.ac.uk/pdbsum/3orf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3orf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/DHPR_DICDI DHPR_DICDI]] The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases (By similarity).  
[https://www.uniprot.org/uniprot/DHPR_DICDI DHPR_DICDI] The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: 6,7-dihydropteridine reductase]]
[[Category: Dictyostelium discoideum]]
[[Category: Dicdi]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Chen, C]]
[[Category: Chen C]]
[[Category: Lee, K H]]
[[Category: Lee KH]]
[[Category: Park, Y S]]
[[Category: Park YS]]
[[Category: Seo, K H]]
[[Category: Seo KH]]
[[Category: Zhuang, N N]]
[[Category: Zhuang NN]]
[[Category: Alpha-beta-alpha sandwich]]
[[Category: Nadh binding]]
[[Category: Oxidoreductase]]
[[Category: Rossmann fold]]

Latest revision as of 16:56, 1 November 2023

Crystal Structure of Dihydropteridine Reductase from Dictyostelium discoideum

3orf, resolution 2.16Å

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