3uky: Difference between revisions

<table><tr><td colspan='2'>[[3uky]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UKY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UKY FirstGlance]. <br>

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ial|1ial]], [[3fex|3fex]], [[3fey|3fey]], [[3ukw|3ukw]], [[3ukx|3ukx]], [[3ukz|3ukz]], [[3ul0|3ul0]], [[3ul1|3ul1]]</div></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Kpna2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), CBP80 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>

[[https://www.uniprot.org/uniprot/IMA2_MOUSE IMA2_MOUSE]] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. [[https://www.uniprot.org/uniprot/NCBP1_YEAST NCBP1_YEAST]] Component of the CBC complex, which binds co-transcriptionally to the 5'-cap of pre-mRNAs and is involved in maturation, export and degradation of nuclear mRNAs. The CBC complex is required for efficient pre-mRNA splicing through efficient commitment complex and spliceosome formation. Together with NPL3, the CBC complex is required for export of mRNAs out of the nucleus. The CBC complex is also involved in nuclear mRNA degradation, probably by directing the mRNAs to the sites of degradation. Affects replication of the positive-strand RNA virus BMV.<ref>PMID:10490594</ref> <ref>PMID:10733586</ref> <ref>PMID:10823828</ref> <ref>PMID:12756324</ref> <ref>PMID:12897126</ref> <ref>PMID:14671320</ref> <ref>PMID:1512188</ref> <ref>PMID:15753296</ref> <ref>PMID:16166263</ref> <ref>PMID:8811086</ref> <ref>PMID:8846890</ref> <ref>PMID:8858145</ref> <ref>PMID:9499403</ref> 

[[Category: Lk3 transgenic mice]]

[[Category: Forwood, J K]]

[[Category: Kobe, B]]

[[Category: Lonhienne, T G]]

[[Category: Marfori, M]]

[[Category: Arm repeat]]

[[Category: Protein transport-protein binding complex]]