5mhk: Difference between revisions
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<StructureSection load='5mhk' size='340' side='right'caption='[[5mhk]], [[Resolution|resolution]] 2.28Å' scene=''> | <StructureSection load='5mhk' size='340' side='right'caption='[[5mhk]], [[Resolution|resolution]] 2.28Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5mhk]] is a 9 chain structure with sequence from [ | <table><tr><td colspan='2'>[[5mhk]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1 Human alphaherpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MHK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MHK FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mhk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mhk OCA], [https://pdbe.org/5mhk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mhk RCSB], [https://www.ebi.ac.uk/pdbsum/5mhk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mhk ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/ICP4_HHV11 ICP4_HHV11] Plays an essential role in the regulation of viral gene expression by both activating and repressing host RNA polymerase II-mediated transcription. Binds with high affinity to the sequence 5'-ATCGTC-3'. Activates transcription by recruiting a form of the host TFIID to promoters and stabilizing the pre-initiation complex formation. Negatively regulates its own transcription. This immediate early (IE) protein is absolutely necessary for the transition from IE transcription to later viral gene transcription.<ref>PMID:18094162</ref> <ref>PMID:18216093</ref> <ref>PMID:1846804</ref> <ref>PMID:22496239</ref> <ref>PMID:23135715</ref> <ref>PMID:24147125</ref> <ref>PMID:8649420</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Human alphaherpesvirus 1]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Baldock | [[Category: Baldock C]] | ||
[[Category: Golovanov | [[Category: Golovanov AP]] | ||
[[Category: Jowitt | [[Category: Jowitt TA]] | ||
[[Category: Levy | [[Category: Levy C]] | ||
[[Category: Lockhart-Cairns | [[Category: Lockhart-Cairns MP]] | ||
[[Category: Mould | [[Category: Mould P]] | ||
[[Category: Sandri-Goldin | [[Category: Sandri-Goldin RM]] | ||
[[Category: Sito | [[Category: Sito H]] | ||
[[Category: Tunnicliffe | [[Category: Tunnicliffe RB]] | ||
