8bd2: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
The entry | ==Calcium-bound Calmodulin variant G113R== | ||
<StructureSection load='8bd2' size='340' side='right'caption='[[8bd2]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8bd2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BD2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BD2 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bd2 OCA], [https://pdbe.org/8bd2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bd2 RCSB], [https://www.ebi.ac.uk/pdbsum/8bd2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bd2 ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/CALM3_HUMAN CALM3_HUMAN] Catecholaminergic polymorphic ventricular tachycardia;Romano-Ward syndrome. The disease may be caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CALM3_HUMAN CALM3_HUMAN] Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding (PubMed:16760425, PubMed:31454269). Calcium-binding is required for the activation of calmodulin (PubMed:35568036, PubMed:16760425, PubMed:31454269). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases (PubMed:16760425, PubMed:35568036). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425).<ref>PMID:16760425</ref> <ref>PMID:31454269</ref> <ref>PMID:35568036</ref> (Microbial infection) Required for C.violaceum CopC arginine ADP-riboxanase activity.<ref>PMID:35338844</ref> <ref>PMID:35446120</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Brohus M]] | |||
[[Category: Holler CV]] | |||
[[Category: Iwai H]] | |||
[[Category: Niemelae MA]] | |||
[[Category: Overgaard MT]] | |||
[[Category: Petersson NM]] | |||
[[Category: Wimmer R]] | |||
Latest revision as of 11:57, 8 November 2023
Calcium-bound Calmodulin variant G113R
| ||||||||||||
