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<StructureSection load='3vsj' size='340' side='right'caption='[[3vsj]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='3vsj' size='340' side='right'caption='[[3vsj]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3vsj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Comamonas_testosteroni Comamonas testosteroni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VSJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VSJ FirstGlance]. <br>
<table><tr><td colspan='2'>[[3vsj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Comamonas_testosteroni_CNB-1 Comamonas testosteroni CNB-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VSJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3VSJ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2X7:(3E)-3-IMINOOXEPIN-2(3H)-ONE'>2X7</scene>, <scene name='pdbligand=2XP:(2Z,4Z)-2-IMINO-6-OXOHEX-4-ENOIC+ACID'>2XP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3vsg|3vsg]], [[3vsh|3vsh]], [[3vsi|3vsi]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2X7:(3E)-3-IMINOOXEPIN-2(3H)-ONE'>2X7</scene>, <scene name='pdbligand=2XP:(2Z,4Z)-2-IMINO-6-OXOHEX-4-ENOIC+ACID'>2XP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Protocatechuate_4,5-dioxygenase Protocatechuate 4,5-dioxygenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.8 1.13.11.8] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vsj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vsj OCA], [https://pdbe.org/3vsj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vsj RCSB], [https://www.ebi.ac.uk/pdbsum/3vsj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vsj ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3vsj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vsj OCA], [https://pdbe.org/3vsj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3vsj RCSB], [https://www.ebi.ac.uk/pdbsum/3vsj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3vsj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/AMNA_COMTE AMNA_COMTE]] Component of the 2-aminophenol 1,6-dioxygenase (APD) complex that catalyzes the ring fission of 2-aminophenol to produce 2-aminomuconic semialdehyde. CnbCa may have a role in the stability of the complex. The complex is also active on other substrates such as 2-amino-5-chlorophenol (68% activity), protocatechuate (33% activity) and catechol (5% activity). Both 2-aminophenol and 2-amino-5-cholorophenol are likely native substrates for this dioxygenase which is involved in the reductive degradation pathway of both nitrobenzene (NB) and 4-chloronitrobenzene (4-CNB), allowing C.testosteroni strain CNB-1 to grow on these compounds as sole source of carbon, nitrogen, and energy.<ref>PMID:15580337</ref> <ref>PMID:16517619</ref> [[https://www.uniprot.org/uniprot/AMNB_COMTE AMNB_COMTE]] Component of the 2-aminophenol 1,6-dioxygenase (APD) complex that catalyzes the ring fission of 2-aminophenol to produce 2-aminomuconic semialdehyde. CnbCb seems to be the catalytic subunit of the complex. Also active on other substrates such as 2-amino-5-chlorophenol (68% activity), protocatechuate (33% activity) and catechol (5% activity). Both 2-aminophenol and 2-amino-5-cholorophenol are likely native substrates for this dioxygenase which is involved in the reductive degradation pathway of both nitrobenzene (NB) and 4-chloronitrobenzene (4-CNB), allowing C.testosteroni strain CNB-1 to grow on these compounds as sole source of carbon, nitrogen, and energy.<ref>PMID:15580337</ref> <ref>PMID:16517619</ref> 
[https://www.uniprot.org/uniprot/AMNA_COMTE AMNA_COMTE] Component of the 2-aminophenol 1,6-dioxygenase (APD) complex that catalyzes the ring fission of 2-aminophenol to produce 2-aminomuconic semialdehyde. CnbCa may have a role in the stability of the complex. The complex is also active on other substrates such as 2-amino-5-chlorophenol (68% activity), protocatechuate (33% activity) and catechol (5% activity). Both 2-aminophenol and 2-amino-5-cholorophenol are likely native substrates for this dioxygenase which is involved in the reductive degradation pathway of both nitrobenzene (NB) and 4-chloronitrobenzene (4-CNB), allowing C.testosteroni strain CNB-1 to grow on these compounds as sole source of carbon, nitrogen, and energy.<ref>PMID:15580337</ref> <ref>PMID:16517619</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Comamonas testosteroni]]
[[Category: Comamonas testosteroni CNB-1]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Protocatechuate 4,5-dioxygenase]]
[[Category: Hou YJ]]
[[Category: Hou, Y J]]
[[Category: Hu Y]]
[[Category: Hu, Y]]
[[Category: Li DF]]
[[Category: Li, D F]]
[[Category: Liu W]]
[[Category: Liu, W]]
[[Category: Wang DC]]
[[Category: Wang, D C]]
[[Category: 2-his-1-carboxylate facial triad motif]]
[[Category: Cnbc]]
[[Category: Extradiol dioxygenase]]
[[Category: Oxidoreductase]]
Retrieved from "https://proteopedia.org/3vsj"