3w4y: Difference between revisions

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<StructureSection load='3w4y' size='340' side='right'caption='[[3w4y]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='3w4y' size='340' side='right'caption='[[3w4y]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3w4y]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W4Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W4Y FirstGlance]. <br>
<table><tr><td colspan='2'>[[3w4y]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W4Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W4Y FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4eoh|4eoh]], [[4eoi|4eoi]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ERV1, ERV1/YGR029W, YGR029W ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Thiol_oxidase Thiol oxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.3.2 1.8.3.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w4y OCA], [https://pdbe.org/3w4y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w4y RCSB], [https://www.ebi.ac.uk/pdbsum/3w4y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w4y ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w4y OCA], [https://pdbe.org/3w4y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w4y RCSB], [https://www.ebi.ac.uk/pdbsum/3w4y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w4y ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/ERV1_YEAST ERV1_YEAST]] FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation. Required for the import and folding of small cysteine-containing proteins in the mitochondrial intermembrane space (IMS). Forms a redox cycle with MIA40 that involves a disulfide relay system. Important for maintaining the cysteine residues in MIA40 in an oxidized state. Reduced ERV1 is reoxidized by cytochrome c. Required for the maturation of cytoplasmic, but not of mitochondrial Fe/S proteins.[PROSITE-ProRule:PRU00654]<ref>PMID:10899311</ref> <ref>PMID:11493598</ref> <ref>PMID:12654008</ref> <ref>PMID:15989955</ref> <ref>PMID:16181637</ref> <ref>PMID:16185707</ref>
[https://www.uniprot.org/uniprot/ERV1_YEAST ERV1_YEAST] FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation. Required for the import and folding of small cysteine-containing proteins in the mitochondrial intermembrane space (IMS). Forms a redox cycle with MIA40 that involves a disulfide relay system. Important for maintaining the cysteine residues in MIA40 in an oxidized state. Reduced ERV1 is reoxidized by cytochrome c. Required for the maturation of cytoplasmic, but not of mitochondrial Fe/S proteins.[PROSITE-ProRule:PRU00654]<ref>PMID:10899311</ref> <ref>PMID:11493598</ref> <ref>PMID:12654008</ref> <ref>PMID:15989955</ref> <ref>PMID:16181637</ref> <ref>PMID:16185707</ref>  


==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Baker's yeast]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Thiol oxidase]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Endo, T]]
[[Category: Endo T]]
[[Category: Kawano, S]]
[[Category: Kawano S]]
[[Category: Terao, K]]
[[Category: Terao K]]
[[Category: Watanabe, N]]
[[Category: Watanabe N]]
[[Category: Alpha helix]]
[[Category: Disulfide bond]]
[[Category: Mitochondria]]
[[Category: Oxidoreductase]]
[[Category: Redox]]
[[Category: Tim40/mia40]]

Latest revision as of 12:49, 8 November 2023

Crystal structure of yeast Erv1 core

3w4y, resolution 2.00Å

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