3waa: Difference between revisions

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<StructureSection load='3waa' size='340' side='right'caption='[[3waa]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='3waa' size='340' side='right'caption='[[3waa]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3waa]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WAA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WAA FirstGlance]. <br>
<table><tr><td colspan='2'>[[3waa]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WAA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WAA FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3wa9|3wa9]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">H3.1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), H4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), H2A.Z.2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), H2B ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3waa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3waa OCA], [https://pdbe.org/3waa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3waa RCSB], [https://www.ebi.ac.uk/pdbsum/3waa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3waa ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3waa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3waa OCA], [https://pdbe.org/3waa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3waa RCSB], [https://www.ebi.ac.uk/pdbsum/3waa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3waa ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>  Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>  [[https://www.uniprot.org/uniprot/H2AV_HUMAN H2AV_HUMAN]] Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity).
[https://www.uniprot.org/uniprot/H31_HUMAN H31_HUMAN]  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Arimura, Y]]
[[Category: Arimura Y]]
[[Category: Harata, M]]
[[Category: Harata M]]
[[Category: Horikoshi, N]]
[[Category: Horikoshi N]]
[[Category: Iwasaki, W]]
[[Category: Iwasaki W]]
[[Category: Kagawa, W]]
[[Category: Kagawa W]]
[[Category: Kimura, H]]
[[Category: Kimura H]]
[[Category: Kurumizaka, H]]
[[Category: Kurumizaka H]]
[[Category: Osakabe, A]]
[[Category: Osakabe A]]
[[Category: Sato, K]]
[[Category: Sato K]]
[[Category: Shimada, K]]
[[Category: Shimada K]]
[[Category: Tachiwana, H]]
[[Category: Tachiwana H]]
[[Category: Chromatin formation]]
[[Category: Dna binding]]
[[Category: Histone fold]]
[[Category: Nucleus]]
[[Category: Structural protein-dna complex]]
Retrieved from "https://proteopedia.org/3waa"