3wcy: Difference between revisions

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<StructureSection load='3wcy' size='340' side='right'caption='[[3wcy]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='3wcy' size='340' side='right'caption='[[3wcy]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3wcy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WCY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WCY FirstGlance]. <br>
<table><tr><td colspan='2'>[[3wcy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WCY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WCY FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3s98|3s98]], [[3se3|3se3]], [[3se4|3se4]], [[1wu3|1wu3]], [[1au1|1au1]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ifar, Ifnar, Ifnar1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Ifb, Ifnb, Ifnb1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wcy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wcy OCA], [https://pdbe.org/3wcy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wcy RCSB], [https://www.ebi.ac.uk/pdbsum/3wcy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wcy ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wcy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wcy OCA], [https://pdbe.org/3wcy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wcy RCSB], [https://www.ebi.ac.uk/pdbsum/3wcy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wcy ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/INAR1_MOUSE INAR1_MOUSE]] Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. [[https://www.uniprot.org/uniprot/IFNB_MOUSE IFNB_MOUSE]] Has antiviral, antibacterial and anticancer activities.  
[https://www.uniprot.org/uniprot/INAR1_MOUSE INAR1_MOUSE] Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves.


==See Also==
==See Also==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Hertzog, P J]]
[[Category: Hertzog PJ]]
[[Category: Rossjohn, J]]
[[Category: Rossjohn J]]
[[Category: Vivian, J P]]
[[Category: Vivian JP]]
[[Category: Weerd, N A.de]]
[[Category: De Weerd NA]]
[[Category: Cytokine receptor]]
[[Category: Cytokine receptor-cytokine complex]]
[[Category: Fibronectin type iii]]
[[Category: Helical cytokine]]
[[Category: Interferon]]

Latest revision as of 13:05, 8 November 2023

Murine Ifnar1 in complex with interferon-beta

3wcy, resolution 2.90Å

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