5mn2: Difference between revisions
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==Cocrystal structure of Fc gamma receptor IIIa interacting with Affimer G3, a specific binding protein which blocks IgG binding to the receptor.== | ==Cocrystal structure of Fc gamma receptor IIIa interacting with Affimer G3, a specific binding protein which blocks IgG binding to the receptor.== | ||
<StructureSection load='5mn2' size='340' side='right' caption='[[5mn2]], [[Resolution|resolution]] 2.35Å' scene=''> | <StructureSection load='5mn2' size='340' side='right'caption='[[5mn2]], [[Resolution|resolution]] 2.35Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5mn2]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[5mn2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MN2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MN2 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mn2 OCA], [https://pdbe.org/5mn2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mn2 RCSB], [https://www.ebi.ac.uk/pdbsum/5mn2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mn2 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
[ | [https://www.uniprot.org/uniprot/FCG3A_HUMAN FCG3A_HUMAN] The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:23006327</ref> <ref>PMID:8608639</ref> <ref>PMID:8609432</ref> <ref>PMID:8874200</ref> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/FCG3A_HUMAN FCG3A_HUMAN] Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.<ref>PMID:21768335</ref> <ref>PMID:22023369</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Synthetic construct | [[Category: Large Structures]] | ||
[[Category: Baxter | [[Category: Synthetic construct]] | ||
[[Category: Goldman | [[Category: Baxter EW]] | ||
[[Category: Harris | [[Category: Goldman A]] | ||
[[Category: McPherson | [[Category: Harris SA]] | ||
[[Category: Morgan | [[Category: McPherson MJ]] | ||
[[Category: Nettleship | [[Category: Morgan AW]] | ||
[[Category: Owen | [[Category: Nettleship JE]] | ||
[[Category: Owens | [[Category: Owen RL]] | ||
[[Category: Robinson | [[Category: Owens RJ]] | ||
[[Category: Thomsen | [[Category: Robinson JI]] | ||
[[Category: Tiede | [[Category: Thomsen M]] | ||
[[Category: Tomlinson | [[Category: Tiede C]] | ||
[[Category: Waterhouse | [[Category: Tomlinson DC]] | ||
[[Category: Waterhouse MP]] | |||
