5mql: Difference between revisions

<table><tr><td colspan='2'>[[5mql]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MQL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MQL FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.25&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DCM:2-DEOXYCYTIDINE-5-MONOPHOSPHATE'>DCM</scene>, <scene name='pdbligand=G65:Masitinib'>G65</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mql OCA], [https://pdbe.org/5mql PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mql RCSB], [https://www.ebi.ac.uk/pdbsum/5mql PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mql ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/DCK_HUMAN DCK_HUMAN] Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.<ref>PMID:18377927</ref> <ref>PMID:20614893</ref>  

[[Category: Homo sapiens]]

[[Category: Audebert S]]

[[Category: Baudelet E]]

[[Category: Betzi S]]

[[Category: Combes S]]

[[Category: Dubreuil P]]

[[Category: Gros L]]

[[Category: Hajem B]]

[[Category: Hammam K]]

[[Category: Humbert M]]

[[Category: Letard S]]

[[Category: Lopez S]]

[[Category: Lugari A]]

[[Category: Mansfield C]]

[[Category: Morelli X]]

[[Category: Moussy A]]

[[Category: Pez D]]

[[Category: Rebuffet E]]

[[Category: Saez-Ayala M]]

[[Category: De Sepulveda P]]