5mqt: Difference between revisions

<table><tr><td colspan='2'>[[5mqt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MQT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MQT FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DCM:2-DEOXYCYTIDINE-5-MONOPHOSPHATE'>DCM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=STI:4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE'>STI</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mqt OCA], [https://pdbe.org/5mqt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mqt RCSB], [https://www.ebi.ac.uk/pdbsum/5mqt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mqt ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/DCK_HUMAN DCK_HUMAN] Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.<ref>PMID:18377927</ref> <ref>PMID:20614893</ref>  

[[Category: Homo sapiens]]

[[Category: Audebert S]]

[[Category: Baudelet E]]

[[Category: Betzi S]]

[[Category: Combes S]]

[[Category: Dubreuil P]]

[[Category: Gros L]]

[[Category: Hajem B]]

[[Category: Hammam K]]

[[Category: Humbert M]]

[[Category: Letard S]]

[[Category: Lopez S]]

[[Category: Lugari A]]

[[Category: Mansfield C]]

[[Category: Morelli X]]

[[Category: Moussy A]]

[[Category: Pez D]]

[[Category: Rebuffet E]]

[[Category: Saez-Ayala M]]

[[Category: De Sepulveda P]]