5mut: Difference between revisions

<table><tr><td colspan='2'>[[5mut]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MUT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MUT FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=HYT:2-METHYL-5-OXIDANYL-~{N}-[2,3,5,6-TETRAKIS(FLUORANYL)-4-PHENYL-PHENYL]-1,2,3-TRIAZOLE-4-CARBOXAMIDE'>HYT</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mut OCA], [https://pdbe.org/5mut PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mut RCSB], [https://www.ebi.ac.uk/pdbsum/5mut PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mut ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[https://omim.org/entry/263750 263750]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>  

[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.

[[Category: Homo sapiens]]

[[Category: Al-Kadaraghi S]]

[[Category: Andersson M]]

[[Category: Boschi D]]

[[Category: Friemann R]]

[[Category: Goyal P]]

[[Category: Lolli M]]

[[Category: Moritzer AC]]

[[Category: Pippione AC]]

[[Category: Sainas S]]