5mvx: Difference between revisions

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<StructureSection load='5mvx' size='340' side='right'caption='[[5mvx]], [[Resolution|resolution]] 2.17&Aring;' scene=''>
<StructureSection load='5mvx' size='340' side='right'caption='[[5mvx]], [[Resolution|resolution]] 2.17&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5mvx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MVX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5MVX FirstGlance]. <br>
<table><tr><td colspan='2'>[[5mvx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MVX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MVX FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.17&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DLL4, UNQ1895/PRO4341 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5mvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mvx OCA], [http://pdbe.org/5mvx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mvx RCSB], [http://www.ebi.ac.uk/pdbsum/5mvx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mvx ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mvx OCA], [https://pdbe.org/5mvx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mvx RCSB], [https://www.ebi.ac.uk/pdbsum/5mvx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mvx ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/DLL4_HUMAN DLL4_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/DLL4_HUMAN DLL4_HUMAN] The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DLL4_HUMAN DLL4_HUMAN]] Involved in the Notch signaling pathway as Notch ligand (PubMed:11134954). Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (PubMed:20616313). Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibits V2a interneuron fate (PubMed:17728344).[UniProtKB:Q9JI71]<ref>PMID:11134954</ref> <ref>PMID:17728344</ref> <ref>PMID:20616313</ref>
[https://www.uniprot.org/uniprot/DLL4_HUMAN DLL4_HUMAN] Involved in the Notch signaling pathway as Notch ligand (PubMed:11134954). Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (PubMed:20616313). Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibits V2a interneuron fate (PubMed:17728344).[UniProtKB:Q9JI71]<ref>PMID:11134954</ref> <ref>PMID:17728344</ref> <ref>PMID:20616313</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Handford, P A]]
[[Category: Handford PA]]
[[Category: Lea, S M]]
[[Category: Lea SM]]
[[Category: Suckling, R J]]
[[Category: Suckling RJ]]
[[Category: C2]]
[[Category: Egf]]
[[Category: Notch]]
[[Category: Signaling]]
[[Category: Signaling protein]]
Retrieved from "https://proteopedia.org/5mvx"