1o7w: Difference between revisions
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'''NAPHTHALENE 1,2-DIOXYGENASE, FULLY REDUCED FORM''' | '''NAPHTHALENE 1,2-DIOXYGENASE, FULLY REDUCED FORM''' | ||
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[[Category: Parales, R E.]] | [[Category: Parales, R E.]] | ||
[[Category: Ramaswamy, S.]] | [[Category: Ramaswamy, S.]] | ||
[[Category: | [[Category: Aromatic hydrocarbon catabolism]] | ||
[[Category: | [[Category: Enzyme-substrate complex,iron-sulfur]] | ||
[[Category: | [[Category: Non-heme iron dioxygenase]] | ||
[[Category: | [[Category: Oxidoreductase]] | ||
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Revision as of 00:29, 3 May 2008
NAPHTHALENE 1,2-DIOXYGENASE, FULLY REDUCED FORM
Overview
Binding of oxygen to iron is exploited in several biological and chemical processes. Although computational and spectroscopic results have suggested side-on binding, only end-on binding of oxygen to iron has been observed in crystal structures. We have determined structures of naphthalene dioxygenase that show a molecular oxygen species bound to the mononuclear iron in a side-on fashion. In a complex with substrate and dioxygen, the dioxygen molecule is lined up for an attack on the double bond of the aromatic substrate. The structures reported here provide the basis for a reaction mechanism and for the high stereospecificity of the reaction catalyzed by naphthalene dioxygenase.
About this Structure
1O7W is a Protein complex structure of sequences from Pseudomonas putida. Full crystallographic information is available from OCA.
Reference
Crystal structure of naphthalene dioxygenase: side-on binding of dioxygen to iron., Karlsson A, Parales JV, Parales RE, Gibson DT, Eklund H, Ramaswamy S, Science. 2003 Feb 14;299(5609):1039-42. PMID:12586937 Page seeded by OCA on Sat May 3 03:29:55 2008
