2y4j: Difference between revisions

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<StructureSection load='2y4j' size='340' side='right'caption='[[2y4j]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='2y4j' size='340' side='right'caption='[[2y4j]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2y4j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_43812 Atcc 43812]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2xw2 2xw2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y4J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y4J FirstGlance]. <br>
<table><tr><td colspan='2'>[[2y4j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rhodothermus_marinus Rhodothermus marinus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2xw2 2xw2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y4J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y4J FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LAC:LACTIC+ACID'>LAC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2bo8|2bo8]], [[2bo6|2bo6]], [[2bo4|2bo4]], [[2bo7|2bo7]], [[2y4l|2y4l]], [[2y4k|2y4k]], [[2y4m|2y4m]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LAC:LACTIC+ACID'>LAC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_synthase Mannosyl-3-phosphoglycerate synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.217 2.4.1.217] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y4j OCA], [https://pdbe.org/2y4j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y4j RCSB], [https://www.ebi.ac.uk/pdbsum/2y4j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y4j ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y4j OCA], [https://pdbe.org/2y4j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y4j RCSB], [https://www.ebi.ac.uk/pdbsum/2y4j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y4j ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/MGS_RHOMR MGS_RHOMR]] Involved in the biosynthesis of the stress protectant 2-O-alpha-D-mannosyl glycerate (MG) which is produced in response to growth at supraoptimal temperature and salinity, and protects several enzymes against inactivation by temperature, freeze-drying and osmotic stress. Catalyzes the condensation of alpha-GDP-D-mannose (GDP-Man) with D-glycerate to produce alpha-mannosyl-D-glycerate. It is specific for GDP-Man, but it can also use alpha-GDP-D-glucose (GDP-Glc), beta-GDP-D-fuctose, alpha-UDP-D-mannose and alpha-UDP-D-glucose as sugar donors. It is specific for D-glycerate, but it can also use D-lactate and glycolate as sugar acceptors. This reaction occurs with a net retention of anomeric configuration; the newly formed glycosidic linkage has the same alpha configuration as the sugar donor.<ref>PMID:10585410</ref> <ref>PMID:15951819</ref> <ref>PMID:21288903</ref>
[https://www.uniprot.org/uniprot/MGS_RHOMR MGS_RHOMR] Involved in the biosynthesis of the stress protectant 2-O-alpha-D-mannosyl glycerate (MG) which is produced in response to growth at supraoptimal temperature and salinity, and protects several enzymes against inactivation by temperature, freeze-drying and osmotic stress. Catalyzes the condensation of alpha-GDP-D-mannose (GDP-Man) with D-glycerate to produce alpha-mannosyl-D-glycerate. It is specific for GDP-Man, but it can also use alpha-GDP-D-glucose (GDP-Glc), beta-GDP-D-fuctose, alpha-UDP-D-mannose and alpha-UDP-D-glucose as sugar donors. It is specific for D-glycerate, but it can also use D-lactate and glycolate as sugar acceptors. This reaction occurs with a net retention of anomeric configuration; the newly formed glycosidic linkage has the same alpha configuration as the sugar donor.<ref>PMID:10585410</ref> <ref>PMID:15951819</ref> <ref>PMID:21288903</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Atcc 43812]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Mannosyl-3-phosphoglycerate synthase]]
[[Category: Rhodothermus marinus]]
[[Category: Barry, C S]]
[[Category: Barry CS]]
[[Category: Davies, G J]]
[[Category: Davies GJ]]
[[Category: Davis, B G]]
[[Category: Davis BG]]
[[Category: Flint, J E]]
[[Category: Flint JE]]
[[Category: Gilbert, H J]]
[[Category: Gilbert HJ]]
[[Category: Martinez-Fleites, C]]
[[Category: Martinez-Fleites C]]
[[Category: Nielsen, M M]]
[[Category: Nielsen MM]]
[[Category: Suits, M D.L]]
[[Category: Suits MDL]]
[[Category: Tailford, L E]]
[[Category: Tailford LE]]
[[Category: Yang, M]]
[[Category: Yang M]]
[[Category: Glycosyltransferase]]
[[Category: Gt family 78 mannosyl-3-phosphoglycerate synthase]]
[[Category: Transferase]]
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