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==Solution structure of MLL4 PHD6 domain in complex with histone H4K16ac peptide==
==Solution structure of MLL4 PHD6 domain in complex with histone H4K16ac peptide==
<StructureSection load='6o7g' size='340' side='right'caption='[[6o7g]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
<StructureSection load='6o7g' size='340' side='right'caption='[[6o7g]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6o7g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O7G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6O7G FirstGlance]. <br>
<table><tr><td colspan='2'>[[6o7g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O7G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6O7G FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KMT2D, ALR, MLL2, MLL4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6o7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o7g OCA], [https://pdbe.org/6o7g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6o7g RCSB], [https://www.ebi.ac.uk/pdbsum/6o7g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6o7g ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o7g OCA], [http://pdbe.org/6o7g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o7g RCSB], [http://www.ebi.ac.uk/pdbsum/6o7g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o7g ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/KMT2D_HUMAN KMT2D_HUMAN]] Kabuki syndrome. The disease is caused by mutations affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/KMT2D_HUMAN KMT2D_HUMAN] Kabuki syndrome. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/KMT2D_HUMAN KMT2D_HUMAN]] Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription.<ref>PMID:16603732</ref> <ref>PMID:17500065</ref> <ref>PMID:17851529</ref>
[https://www.uniprot.org/uniprot/KMT2D_HUMAN KMT2D_HUMAN] Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription.<ref>PMID:16603732</ref> <ref>PMID:17500065</ref> <ref>PMID:17851529</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6o7g" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6o7g" style="background-color:#fffaf0;"></div>
==See Also==
*[[Histone 3D structures|Histone 3D structures]]
*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Histone-lysine N-methyltransferase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Kutateladze, T G]]
[[Category: Kutateladze TG]]
[[Category: Zhang, Y]]
[[Category: Zhang Y]]
[[Category: Acetylation]]
[[Category: Chromatin]]
[[Category: H4k16ac]]
[[Category: Histone]]
[[Category: Mll4]]
[[Category: Mof]]
[[Category: Phd finger]]
[[Category: Transcription]]
Retrieved from "https://proteopedia.org/6o7g"