5n9s: Difference between revisions

<table><tr><td colspan='2'>[[5n9s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N9S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5N9S FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8QW:(2~{R})-2-(4-fluorophenyl)-~{N}-[4-[2-[(2-methoxy-4-methylsulfonyl-phenyl)amino]-[1,2,4]triazolo[1,5-a]pyridin-6-yl]phenyl]propanamide'>8QW</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5n9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n9s OCA], [https://pdbe.org/5n9s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5n9s RCSB], [https://www.ebi.ac.uk/pdbsum/5n9s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5n9s ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>  

[[Category: Homo sapiens]]

[[Category: Buijsman RC]]

[[Category: Uitdehaag J]]

[[Category: Willemsen-Seegers N]]

[[Category: Zaman GJR]]

[[Category: De Man J]]