5nf2: Difference between revisions

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<StructureSection load='5nf2' size='340' side='right'caption='[[5nf2]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
<StructureSection load='5nf2' size='340' side='right'caption='[[5nf2]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5nf2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NF2 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5NF2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5nf2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Porphyromonas_gingivalis_ATCC_33277 Porphyromonas gingivalis ATCC 33277]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NF2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NF2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.73&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5nf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nf2 OCA], [http://pdbe.org/5nf2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nf2 RCSB], [http://www.ebi.ac.uk/pdbsum/5nf2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nf2 ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nf2 OCA], [https://pdbe.org/5nf2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nf2 RCSB], [https://www.ebi.ac.uk/pdbsum/5nf2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nf2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MFA1_PORG3 MFA1_PORG3]] Structural subunit of the minor fimbriae (PubMed:12593606, PubMed:19589838, PubMed:24118823). These filamentous pili are attached to the cell surface; they mediate biofilm formation, adhesion onto host cells and onto other bacteria that are part of the oral microbiome (PubMed:11083792, PubMed:12593606, PubMed:15972485, PubMed:19589838, PubMed:23809984, PubMed:24118823, PubMed:26001707, PubMed:26437277). They play an important role in invasion of periodontal tissues and are recognized as major virulence factors. Mfa1 orthologs from different strains have highly divergent sequences, and this correlates with pathogenicity (Probable).<ref>PMID:11083792</ref> <ref>PMID:12593606</ref> <ref>PMID:15972485</ref> <ref>PMID:19589838</ref> <ref>PMID:23809984</ref> <ref>PMID:24118823</ref> <ref>PMID:26001707</ref> <ref>PMID:26437277</ref>
[https://www.uniprot.org/uniprot/MFA1_PORG3 MFA1_PORG3] Structural subunit of the minor fimbriae (PubMed:12593606, PubMed:19589838, PubMed:24118823). These filamentous pili are attached to the cell surface; they mediate biofilm formation, adhesion onto host cells and onto other bacteria that are part of the oral microbiome (PubMed:11083792, PubMed:12593606, PubMed:15972485, PubMed:19589838, PubMed:23809984, PubMed:24118823, PubMed:26001707, PubMed:26437277). They play an important role in invasion of periodontal tissues and are recognized as major virulence factors. Mfa1 orthologs from different strains have highly divergent sequences, and this correlates with pathogenicity (Probable).<ref>PMID:11083792</ref> <ref>PMID:12593606</ref> <ref>PMID:15972485</ref> <ref>PMID:19589838</ref> <ref>PMID:23809984</ref> <ref>PMID:24118823</ref> <ref>PMID:26001707</ref> <ref>PMID:26437277</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Hall, M]]
[[Category: Porphyromonas gingivalis ATCC 33277]]
[[Category: Hasegawa, Y]]
[[Category: Hall M]]
[[Category: Persson, K]]
[[Category: Hasegawa Y]]
[[Category: Adhesin]]
[[Category: Persson K]]
[[Category: Cell adhesion]]
[[Category: Fimbria]]
[[Category: Periodontitis]]