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| | '''Unreleased structure''' |
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| ==Structure of human SGLT2-MAP17 complex with Sotagliflozin==
| | The entry 8hg7 is ON HOLD until 2024-11-14 |
| <StructureSection load='8hg7' size='340' side='right'caption='[[8hg7]], [[Resolution|resolution]] 3.10Å' scene=''>
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| == Structural highlights ==
| | Authors: Masahiro, H., Hioryuki, K., Ikuko, M., Osamu, N. |
| <table><tr><td colspan='2'>[[8hg7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HG7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HG7 FirstGlance]. <br>
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| </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1Å</td></tr>
| | Description: Structure of human SGLT2-MAP17 complex with Sotagliflozin |
| <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LFL:(2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[(4-ethoxyphenyl)methyl]phenyl]-6-methylsulfanyl-oxane-3,4,5-triol'>LFL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
| | [[Category: Unreleased Structures]] |
| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hg7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hg7 OCA], [https://pdbe.org/8hg7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hg7 RCSB], [https://www.ebi.ac.uk/pdbsum/8hg7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hg7 ProSAT]</span></td></tr>
| | [[Category: Ikuko, M]] |
| </table>
| | [[Category: Osamu, N]] |
| == Disease ==
| | [[Category: Hioryuki, K]] |
| [https://www.uniprot.org/uniprot/SC5A2_HUMAN SC5A2_HUMAN] Familial renal glucosuria. The disease is caused by variants affecting the gene represented in this entry.
| | [[Category: Masahiro, H]] |
| == Function ==
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| [https://www.uniprot.org/uniprot/SC5A2_HUMAN SC5A2_HUMAN] Electrogenic Na(+)-coupled sugar simporter that actively transports D-glucose at the plasma membrane, with a Na(+) to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (PubMed:20980548, PubMed:28592437, PubMed:34880493). Has a primary role in D-glucose reabsorption from glomerular filtrate across the brush border of the early proximal tubules of the kidney (By similarity).[UniProtKB:Q923I7]<ref>PMID:20980548</ref> <ref>PMID:28592437</ref> <ref>PMID:34880493</ref>
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| == References ==
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| <references/>
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| __TOC__
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| </StructureSection>
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| [[Category: Homo sapiens]] | |
| [[Category: Large Structures]]
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| [[Category: Hiraizumi M]] | |
| [[Category: Kishida H]] | |
| [[Category: Miyaguchi I]] | |
| [[Category: Nureki O]] | |
Unreleased structure
The entry 8hg7 is ON HOLD until 2024-11-14
Authors: Masahiro, H., Hioryuki, K., Ikuko, M., Osamu, N.
Description: Structure of human SGLT2-MAP17 complex with Sotagliflozin
