5x74: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==The crystal Structure PDE delta in complex with compound (R, R)-1g== | ==The crystal Structure PDE delta in complex with compound (R, R)-1g== | ||
<StructureSection load='5x74' size='340' side='right' caption='[[5x74]], [[Resolution|resolution]] 2.25Å' scene=''> | <StructureSection load='5x74' size='340' side='right'caption='[[5x74]], [[Resolution|resolution]] 2.25Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5x74]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[5x74]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X74 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5X74 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JAY:(2R)-2-(2-fluorophenyl)-3-[2-[4-[(2R)-2-(2-fluorophenyl)-4-oxidanylidene-1,2-dihydroquinazolin-3-yl]piperidin-1-yl]ethyl]-1,2-dihydroquinazolin-4-one'>JAY</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JAY:(2R)-2-(2-fluorophenyl)-3-[2-[4-[(2R)-2-(2-fluorophenyl)-4-oxidanylidene-1,2-dihydroquinazolin-3-yl]piperidin-1-yl]ethyl]-1,2-dihydroquinazolin-4-one'>JAY</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5x74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x74 OCA], [https://pdbe.org/5x74 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5x74 RCSB], [https://www.ebi.ac.uk/pdbsum/5x74 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5x74 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/PDE6D_HUMAN PDE6D_HUMAN] Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 24: | Line 23: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Chen | [[Category: Large Structures]] | ||
[[Category: Jiang | [[Category: Chen L]] | ||
[[Category: Sheng | [[Category: Jiang Y]] | ||
[[Category: Wang | [[Category: Sheng C]] | ||
[[Category: Wang | [[Category: Wang F]] | ||
[[Category: Zhuang | [[Category: Wang R]] | ||
[[Category: Zhuang C]] | |||
Latest revision as of 07:55, 22 November 2023
The crystal Structure PDE delta in complex with compound (R, R)-1g
| ||||||||||||
