5x80: Difference between revisions

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<StructureSection load='5x80' size='340' side='right'caption='[[5x80]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='5x80' size='340' side='right'caption='[[5x80]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5x80]] is a 4 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5hsn 5hsn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X80 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5X80 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5x80]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5hsn 5hsn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X80 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5X80 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAL:2-HYDROXYBENZOIC+ACID'>SAL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5hsn|5hsn]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAL:2-HYDROXYBENZOIC+ACID'>SAL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5x80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x80 OCA], [http://pdbe.org/5x80 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x80 RCSB], [http://www.ebi.ac.uk/pdbsum/5x80 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x80 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5x80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x80 OCA], [https://pdbe.org/5x80 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5x80 RCSB], [https://www.ebi.ac.uk/pdbsum/5x80 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5x80 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HTMR_MYCTU HTMR_MYCTU] Represses expression of the HQNO methyltransferase htm gene (Rv0560c) by binding to its promoter region (PubMed:26303802, PubMed:27432954, PubMed:28743871). Also represses the expression of at least five other genes, including the methyltransferase Rv0558 (PubMed:26303802). Binds salicylate (SA), para-aminosalicylic acid (PAS) and gemfibrozil (PubMed:28743871).<ref>PMID:26303802</ref> <ref>PMID:27432954</ref> <ref>PMID:28743871</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Bi, L J]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Gao, Y R]]
[[Category: Bi LJ]]
[[Category: Li, D F]]
[[Category: Gao YR]]
[[Category: Wang, D C]]
[[Category: Li DF]]
[[Category: Dna binding]]
[[Category: Wang DC]]
[[Category: Hth-type transcriptional regulator]]
[[Category: P-aminosalicylic acid binding]]
[[Category: Salicylic acid binding]]
[[Category: Transcription]]
[[Category: Whth motif]]
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