5xjv: Difference between revisions

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<StructureSection load='5xjv' size='340' side='right'caption='[[5xjv]], [[Resolution|resolution]] 1.69&Aring;' scene=''>
<StructureSection load='5xjv' size='340' side='right'caption='[[5xjv]], [[Resolution|resolution]] 1.69&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5xjv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XJV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XJV FirstGlance]. <br>
<table><tr><td colspan='2'>[[5xjv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XJV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XJV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.69&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DUSP13, BEDP, DUSP13A, MDSP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xjv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xjv OCA], [https://pdbe.org/5xjv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xjv RCSB], [https://www.ebi.ac.uk/pdbsum/5xjv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xjv ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xjv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xjv OCA], [https://pdbe.org/5xjv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xjv RCSB], [https://www.ebi.ac.uk/pdbsum/5xjv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xjv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/DS13A_HUMAN DS13A_HUMAN]] Probable protein tyrosine phosphatase. Has a phosphatase activity-independent regulatory role in MAP3K5/ASK1-mediated apoptosis, preventing MAP3K5/ASK1 inhibition by AKT1. Shows no phosphatase activity on MAPK1/ERK2, MAPK8/JNK, MAPK14/p38 and MAP3K5/ASK1.<ref>PMID:20358250</ref>
[https://www.uniprot.org/uniprot/DS13A_HUMAN DS13A_HUMAN] Probable protein tyrosine phosphatase. Has a phosphatase activity-independent regulatory role in MAP3K5/ASK1-mediated apoptosis, preventing MAP3K5/ASK1 inhibition by AKT1. Shows no phosphatase activity on MAPK1/ERK2, MAPK8/JNK, MAPK14/p38 and MAP3K5/ASK1.<ref>PMID:20358250</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Chun, H J]]
[[Category: Chun HJ]]
[[Category: Min, H G]]
[[Category: Min HG]]
[[Category: Ryu, S E]]
[[Category: Ryu SE]]
[[Category: Wei, C H]]
[[Category: Wei CH]]
[[Category: Catalytic domain]]
[[Category: Conformation switch]]
[[Category: Dusp13a]]
[[Category: Hydrolase]]
[[Category: Ptp]]
Retrieved from "https://proteopedia.org/5xjv"