5xo1

Crystal structure of the isochorismatase domain of VabB from Vibrio anguillarum 775

spinqualitylabelsall models 5xo1, resolution 2.23Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5xo1 is a 6 chain structure with sequence from Vibrio anguillarum 775. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.23Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q5DK16_VIBA7 Publication Abstract from PubMed Antibiotic resistance is becoming a global threat and overuse of antibiotics in aquaculture disease control worsens the situation. To reduce the risk of drug resistance developed in aquaculture, safer biocontrol programs are needed. Antivirulence therapy, with less chance for developing drug resistance, is a promising approach. To facilitate antivirulence inhibitor design against Vibrio anguillarum, a serious aquaculture pathogen, we present crystal structures for isochorismatase domains of AngB and VabB, which are required to synthesize siderophore, a critical virulence factor. Both structures are highly similar to known isochorismatases in fold and active site, therefore we conclude inhibitors for isochorismatases can be developed in a common framework. The structural information will improve design of virulence inhibitors against Vibrio anguillarum. We also firstly report that isochorismatase family could bind endogenous metabolite during the hetero-expression process, which is likely nicotinic acid, nicotinamide or pyrazinic acid, based on structural analysis and affinity prediction. Taken together, our results provide precise structural information of isochorismatase domains for antivirulence inhibitor design against Vibrio anguillarum. Crystal structures of the isochorismatase domains from Vibrio anguillarum.,Du J, Deng T, Ma Q Biochem Biophys Res Commun. 2017 Aug 26;490(3):827-833. doi:, 10.1016/j.bbrc.2017.06.125. Epub 2017 Jun 21. PMID:28647364 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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