5yzc

Crystal structure of the prefusion form of measles virus fusion protein in complex with a fusion inhibitor compound (AS-48)

spinqualitylabelsall models 5yzc, resolution 2.33Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5yzc is a 2 chain structure with sequence from Measles morbillivirus and Measles virus strain Ichinose-B95a. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.334Å Ligands: 95C, NAG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function FUS_MEASC Publication Abstract from PubMed Measles virus (MeV), a major cause of childhood morbidity and mortality, is highly immunotropic and one of the most contagious pathogens. MeV may establish, albeit rarely, persistent infection in the central nervous system, causing fatal and intractable neurodegenerative diseases such as subacute sclerosing panencephalitis and measles inclusion body encephalitis. Recent studies have suggested that particular substitutions in the MeV fusion (F) protein are involved in the pathogenesis by destabilizing the F protein and endowing it with hyperfusogenicity. Here we show the crystal structures of the prefusion MeV-F alone and in complex with the small compound AS-48 or a fusion inhibitor peptide. Notably, these independently developed inhibitors bind the same hydrophobic pocket located at the region connecting the head and stalk of MeV-F, where a number of substitutions in MeV isolates from neurodegenerative diseases are also localized. Since these inhibitors could suppress membrane fusion mediated by most of the hyperfusogenic MeV-F mutants, the development of more effective inhibitors based on the structures may be warranted to treat MeV-induced neurodegenerative diseases. Structures of the prefusion form of measles virus fusion protein in complex with inhibitors.,Hashiguchi T, Fukuda Y, Matsuoka R, Kuroda D, Kubota M, Shirogane Y, Watanabe S, Tsumoto K, Kohda D, Plemper RK, Yanagi Y Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2496-2501. doi:, 10.1073/pnas.1718957115. Epub 2018 Feb 20. PMID:29463726 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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