5yzp: Difference between revisions
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<StructureSection load='5yzp' size='340' side='right'caption='[[5yzp]], [[Resolution|resolution]] 1.58Å' scene=''> | <StructureSection load='5yzp' size='340' side='right'caption='[[5yzp]], [[Resolution|resolution]] 1.58Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5yzp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[5yzp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus_domesticus Mus musculus domesticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YZP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YZP FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.581Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yzp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yzp OCA], [https://pdbe.org/5yzp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yzp RCSB], [https://www.ebi.ac.uk/pdbsum/5yzp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yzp ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yzp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yzp OCA], [https://pdbe.org/5yzp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yzp RCSB], [https://www.ebi.ac.uk/pdbsum/5yzp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yzp ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/IFI4_MOUSE IFI4_MOUSE] Inhibits the transcription of ribosomal RNA. May inhibit DNA binding by UBTF. Inhibits cell growth via p53/TP53 and RB1-dependent and independent pathways. Acts as a coactivator of RUNX2 during osteogenesis. May be involved in macrophage differentiation. Enables skeletal muscle and cardiac myocyte differentiation by sequestring Id proteins in the cytosol and promoting their ubiquitination and subsequent degradation.<ref>PMID:10329630</ref> <ref>PMID:11940648</ref> <ref>PMID:15557274</ref> <ref>PMID:16244109</ref> <ref>PMID:16458891</ref> <ref>PMID:16556595</ref> <ref>PMID:16556596</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Mus domesticus]] | [[Category: Mus musculus domesticus]] | ||
[[Category: Jin | [[Category: Jin T]] | ||
