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==Crystal structure of the nucleosome containing a chimeric histone H3/CENP-A CATD==
==Crystal structure of the nucleosome containing a chimeric histone H3/CENP-A CATD==
<StructureSection load='5z23' size='340' side='right' caption='[[5z23]], [[Resolution|resolution]] 2.73&Aring;' scene=''>
<StructureSection load='5z23' size='340' side='right'caption='[[5z23]], [[Resolution|resolution]] 2.73&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5z23]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z23 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Z23 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5z23]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z23 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Z23 FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.73&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5z23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z23 OCA], [http://pdbe.org/5z23 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z23 RCSB], [http://www.ebi.ac.uk/pdbsum/5z23 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z23 ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5z23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z23 OCA], [https://pdbe.org/5z23 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5z23 RCSB], [https://www.ebi.ac.uk/pdbsum/5z23 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5z23 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/H2B1J_HUMAN H2B1J_HUMAN]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>  Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.<ref>PMID:11859126</ref> <ref>PMID:12860195</ref> <ref>PMID:15019208</ref>
[https://www.uniprot.org/uniprot/H31_HUMAN H31_HUMAN] [https://www.uniprot.org/uniprot/CENPA_HUMAN CENPA_HUMAN] Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).<ref>PMID:20739937</ref> <ref>PMID:21478274</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Arimura, Y]]
[[Category: Homo sapiens]]
[[Category: Tachiwana, H]]
[[Category: Large Structures]]
[[Category: Takagi, H]]
[[Category: Arimura Y]]
[[Category: Cenp-a]]
[[Category: Tachiwana H]]
[[Category: Centromere]]
[[Category: Takagi H]]
[[Category: Chromosome]]
[[Category: Dna binding protein]]
[[Category: Dna binding protein-dna complex]]
[[Category: Nucleosome]]
Retrieved from "https://proteopedia.org/5z23"