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<StructureSection load='5zja' size='340' side='right'caption='[[5zja]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='5zja' size='340' side='right'caption='[[5zja]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5zja]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZJA OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5ZJA FirstGlance]. <br>
<table><tr><td colspan='2'>[[5zja]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZJA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZJA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9E9:5-chloro+thiophene-2-carboxylic+acid'>9E9</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5zj9|5zj9]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9E9:5-chloro+thiophene-2-carboxylic+acid'>9E9</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/D-amino-acid_oxidase D-amino-acid oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.3 1.4.3.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zja OCA], [https://pdbe.org/5zja PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zja RCSB], [https://www.ebi.ac.uk/pdbsum/5zja PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zja ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5zja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zja OCA], [http://pdbe.org/5zja PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zja RCSB], [http://www.ebi.ac.uk/pdbsum/5zja PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zja ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/OXDA_HUMAN OXDA_HUMAN]] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.<ref>PMID:17303072</ref>
[https://www.uniprot.org/uniprot/OXDA_HUMAN OXDA_HUMAN] Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.<ref>PMID:17303072</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: D-amino-acid oxidase]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Fukui, K]]
[[Category: Fukui K]]
[[Category: Hin, N]]
[[Category: Hin N]]
[[Category: Kato, Y]]
[[Category: Kato Y]]
[[Category: Kurosawa, S]]
[[Category: Kurosawa S]]
[[Category: Maita, N]]
[[Category: Maita N]]
[[Category: Rojas, C]]
[[Category: Rojas C]]
[[Category: Slusher, B S]]
[[Category: Slusher BS]]
[[Category: Thomas, A G]]
[[Category: Thomas AG]]
[[Category: Tsukamoto, T]]
[[Category: Tsukamoto T]]
[[Category: Yorita, K]]
[[Category: Yorita K]]
[[Category: D-amino acid]]
[[Category: Flavoenzyme]]
[[Category: Oxidoreductase]]
Retrieved from "https://proteopedia.org/5zja"