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==Crystal structure of mouse nectin-like molecule 4 (mNecl-4) full ectodomain in complex with mouse nectin-like molecule 1 (mNecl-1) Ig1 domain, 3.3A==
==Crystal structure of mouse nectin-like molecule 4 (mNecl-4) full ectodomain in complex with mouse nectin-like molecule 1 (mNecl-1) Ig1 domain, 3.3A==
<StructureSection load='5zo2' size='340' side='right' caption='[[5zo2]], [[Resolution|resolution]] 3.29&Aring;' scene=''>
<StructureSection load='5zo2' size='340' side='right'caption='[[5zo2]], [[Resolution|resolution]] 3.29&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5zo2]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZO2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZO2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5zo2]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZO2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZO2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.29&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1z9m|1z9m]], [[5zo1|5zo1]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cadm4, Igsf4c, Necl4, Tsll2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Cadm3, Igsf4b, Necl1, Syncam3, Tsll1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zo2 OCA], [https://pdbe.org/5zo2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zo2 RCSB], [https://www.ebi.ac.uk/pdbsum/5zo2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zo2 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zo2 OCA], [http://pdbe.org/5zo2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zo2 RCSB], [http://www.ebi.ac.uk/pdbsum/5zo2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zo2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CADM4_MOUSE CADM4_MOUSE]] Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor-suppressor activity.<ref>PMID:14659875</ref> [[http://www.uniprot.org/uniprot/CADM3_MOUSE CADM3_MOUSE]] Involved in the cell-cell adhesion. Has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions.<ref>PMID:15741237</ref> <ref>PMID:15893517</ref> 
[https://www.uniprot.org/uniprot/CADM4_MOUSE CADM4_MOUSE] Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor-suppressor activity.<ref>PMID:14659875</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: An, T]]
[[Category: Mus musculus]]
[[Category: Cui, S]]
[[Category: An T]]
[[Category: Fan, Z]]
[[Category: Cui S]]
[[Category: Hu, G]]
[[Category: Fan Z]]
[[Category: Ju, W]]
[[Category: Hu G]]
[[Category: Li, C]]
[[Category: Ju W]]
[[Category: Li, D]]
[[Category: Li C]]
[[Category: Li, J]]
[[Category: Li D]]
[[Category: Liu, X]]
[[Category: Li J]]
[[Category: Peng, X]]
[[Category: Liu X]]
[[Category: Qiang, B]]
[[Category: Peng X]]
[[Category: Qin, B]]
[[Category: Qiang B]]
[[Category: Shu, P]]
[[Category: Qin B]]
[[Category: Wang, M]]
[[Category: Shu P]]
[[Category: Wojdyla, J A]]
[[Category: Wang M]]
[[Category: Xiang, P]]
[[Category: Wojdyla JA]]
[[Category: Yin, B]]
[[Category: Xiang P]]
[[Category: Yuan, J]]
[[Category: Yin B]]
[[Category: Axon]]
[[Category: Yuan J]]
[[Category: Cadm]]
[[Category: Cell adhesion]]
[[Category: Cell adhesion molecule]]
[[Category: Glycoprotein]]
[[Category: Heterogeneous dimer]]
[[Category: Ig domain]]
[[Category: Molecular replacement]]
[[Category: Myelogenesis]]
[[Category: Necl-1]]
[[Category: Necl-4]]
[[Category: Nectin-like]]
[[Category: Schwann cell]]
[[Category: Syncam]]
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