6ich: Difference between revisions

<table><tr><td colspan='2'>[[6ich]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ICH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ICH FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ich FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ich OCA], [https://pdbe.org/6ich PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ich RCSB], [https://www.ebi.ac.uk/pdbsum/6ich PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ich ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/GRB2_HUMAN GRB2_HUMAN] Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref>  Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref>  

[[Category: Abe R]]

[[Category: Hosoe Y]]

[[Category: Inaba S]]

[[Category: Ito N]]

[[Category: Morii H]]

[[Category: Numoto N]]

[[Category: Oda M]]

[[Category: Ogawa S]]