6ifc: Difference between revisions

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<StructureSection load='6ifc' size='340' side='right'caption='[[6ifc]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
<StructureSection load='6ifc' size='340' side='right'caption='[[6ifc]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6ifc]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Salty Salty]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IFC FirstGlance]. <br>
<table><tr><td colspan='2'>[[6ifc]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IFC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IFC FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.99&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">vapC, STM3033 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 SALTY]), vapB, STM3034 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 SALTY])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ifc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ifc OCA], [http://pdbe.org/6ifc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ifc RCSB], [http://www.ebi.ac.uk/pdbsum/6ifc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ifc ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ifc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ifc OCA], [https://pdbe.org/6ifc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ifc RCSB], [https://www.ebi.ac.uk/pdbsum/6ifc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ifc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/VAPC_SALTY VAPC_SALTY]] Toxic component of a type II toxin-antitoxin (TA) system. A site-specific tRNA-(fMet) endonuclease, it cleaves both charged and uncharged tRNA-(fMet) between positions 38 and 39 at the anticodon stem-loop boundary. Does not cleave tRNA(Met), tRNA(Arg2), tRNA(His), tRNA(Leu), tRNA(Phe) tRNA(Thr1), tRNA(Tyr) or tRNA(Val). Overexpression in E.coli inhibits translation, leads to loss of cell growth and degradation of tRNA(fMet), these effects are neutralized by expression of cognate antitoxin VapB. Expression also activates translation initiation at correctly positioned elongator codons (AAA and to a lesser extent AAG).  Ectopic overexpression in E.coli induces the YoeB toxin, but this is not the cause of VapC toxicity. [[http://www.uniprot.org/uniprot/VAPB_SALTY VAPB_SALTY]] Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli neutralizes the effect of cognate toxin VapC.<ref>PMID:19400780</ref> <ref>PMID:21502523</ref>
[https://www.uniprot.org/uniprot/VAPB_SALTY VAPB_SALTY] Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in E.coli neutralizes the effect of cognate toxin VapC.<ref>PMID:19400780</ref> <ref>PMID:21502523</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6ifc" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6ifc" style="background-color:#fffaf0;"></div>
==See Also==
*[[Endonuclease 3D structures|Endonuclease 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Salty]]
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
[[Category: Lee, B J]]
[[Category: Lee BJ]]
[[Category: Park, D W]]
[[Category: Park DW]]
[[Category: Toxin-antitoxin]]
[[Category: Toxin-antitoxin complex]]
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