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| <StructureSection load='6j0y' size='340' side='right'caption='[[6j0y]], [[Resolution|resolution]] 1.80Å' scene=''> | | <StructureSection load='6j0y' size='340' side='right'caption='[[6j0y]], [[Resolution|resolution]] 1.80Å' scene=''> |
| == Structural highlights == | | == Structural highlights == |
| <table><tr><td colspan='2'>[[6j0y]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J0Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6J0Y FirstGlance]. <br> | | <table><tr><td colspan='2'>[[6j0y]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6J0Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6J0Y FirstGlance]. <br> |
| </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6j0w|6j0w]]</td></tr> | | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> |
| <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RTT107, ESC4, YHR154W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), SLX4, YLR135W, L3140 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
| | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6j0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j0y OCA], [https://pdbe.org/6j0y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6j0y RCSB], [https://www.ebi.ac.uk/pdbsum/6j0y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6j0y ProSAT]</span></td></tr> |
| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6j0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6j0y OCA], [http://pdbe.org/6j0y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6j0y RCSB], [http://www.ebi.ac.uk/pdbsum/6j0y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6j0y ProSAT]</span></td></tr> | |
| </table> | | </table> |
| == Function == | | == Function == |
| [[http://www.uniprot.org/uniprot/RT107_YEAST RT107_YEAST]] Required for resumption of chromosome replication after DNA damage, specifically in S phase. Is recruited to chromatin in the presence of RTT109 and RTT101 in response to stalled replication forks and acts as a scaffold during DNA repair.<ref>PMID:14988729</ref> <ref>PMID:17978089</ref> [[http://www.uniprot.org/uniprot/SLX4_YEAST SLX4_YEAST]] Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for simple Y, 5'-flap and replication fork-like structures. It cleaves the strand bearing the 5'-non-homologous arm at the branch site junction and generates ligatable, nicked products from the 5'-flap or replication fork substrates. Plays a critical role in maintaining the integrity of the ribosomal DNA (rDNA) loci, where it has a role in re-starting stalled replication forks. Has Holliday junction resolvase activity in vitro. Interacts with the structure-specific RAD1-RAD10 endonuclease and promotes RAD1-RAD10-dependent 3'-non-homologous tail removal (NHTR) during repair of double-strand breaks by single-strand annealing. SLX4 also promotes recovery from DNA-alkylation-induced replisome stalling during DNA replication by facilitating the error-free mode of lesion bypass. This does not require SLX1 or RAD1-RAD10, but probably RTT107.[HAMAP-Rule:MF_03110]<ref>PMID:11139495</ref> <ref>PMID:12228808</ref> <ref>PMID:12832395</ref> <ref>PMID:15834151</ref> <ref>PMID:15975089</ref> <ref>PMID:16267268</ref> <ref>PMID:17636031</ref> <ref>PMID:18471978</ref> <ref>PMID:18579504</ref> | | [https://www.uniprot.org/uniprot/RT107_YEAST RT107_YEAST] Required for resumption of chromosome replication after DNA damage, specifically in S phase. Is recruited to chromatin in the presence of RTT109 and RTT101 in response to stalled replication forks and acts as a scaffold during DNA repair.<ref>PMID:14988729</ref> <ref>PMID:17978089</ref> |
| <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| __TOC__ | | __TOC__ |
| </StructureSection> | | </StructureSection> |
| [[Category: Baker's yeast]]
| |
| [[Category: Large Structures]] | | [[Category: Large Structures]] |
| [[Category: Lei, M]] | | [[Category: Saccharomyces cerevisiae S288C]] |
| [[Category: Wan, B]] | | [[Category: Lei M]] |
| [[Category: Wu, J]] | | [[Category: Wan B]] |
| [[Category: Brct domain]] | | [[Category: Wu J]] |
| [[Category: Mitosis]]
| |
| [[Category: Protein binding]]
| |
| [[Category: Protein interaction]]
| |
