6k0l: Difference between revisions

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<StructureSection load='6k0l' size='340' side='right'caption='[[6k0l]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
<StructureSection load='6k0l' size='340' side='right'caption='[[6k0l]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6k0l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/African_green_monkey African green monkey]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6K0L FirstGlance]. <br>
<table><tr><td colspan='2'>[[6k0l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Chlorocebus_aethiops Chlorocebus aethiops]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6K0L FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD163, M130 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9534 African green monkey])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6k0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k0l OCA], [https://pdbe.org/6k0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6k0l RCSB], [https://www.ebi.ac.uk/pdbsum/6k0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6k0l ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6k0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k0l OCA], [https://pdbe.org/6k0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6k0l RCSB], [https://www.ebi.ac.uk/pdbsum/6k0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6k0l ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/C163A_CHLAE C163A_CHLAE]] Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity).  After shedding, the soluble form (sCD163) may play an anti-inflammatory role.  
[https://www.uniprot.org/uniprot/C163A_CHLAE C163A_CHLAE] Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity).  After shedding, the soluble form (sCD163) may play an anti-inflammatory role.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: African green monkey]]
[[Category: Chlorocebus aethiops]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Jiang, L]]
[[Category: Jiang L]]
[[Category: Li, R]]
[[Category: Li R]]
[[Category: Ma, H]]
[[Category: Ma H]]
[[Category: Qiao, S]]
[[Category: Qiao S]]
[[Category: Zhang, G]]
[[Category: Zhang G]]
[[Category: Endocytosis]]
[[Category: Porcine reproductive and respiratory syndrome virus]]
[[Category: Scavenger receptor]]
[[Category: Scavenger receptor cysteine-rich domain]]
Retrieved from "https://proteopedia.org/6k0l"